By Didier Raoult, Philippe Parola
ISBN-10: 0849376114
ISBN-13: 9780849376115
Книга Rickettsial illnesses Rickettsial DiseasesКниги Медицина Автор: Didier Raoult, Philippe Parola Год издания: 2007 Формат: pdf Издат.:Informa Healthcare Страниц: four hundred Размер: 4,9 ISBN: 0849376114 Язык: Английский0 (голосов: zero) Оценка:The purely to be had connection with comprehensively talk about the typical and strange varieties of rickettsiosis in over 20 years, this ebook will provide the reader a whole overview at the bacteriology, transmission, and pathophysiology of those stipulations. Written from specialists within the box from Europe, united states, Africa, and Asia, experts learn particular pathogens on the epidemiological, microbiological, and molecular degrees, and talk about the newest developments within the analysis, administration, and therapy of rickettsial ailments.
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Example text
Infect Immun 2001; 69:1841–1846. 26. Walker DH, Popov VL, Crocquet-Valdes PA, et al. Cytokine-induced, nitric oxide-dependent, intracellular antirickettsial activity of mouse endothelial cells. Lab Invest 1997; 76:129–138. 27. Feng HM, Walker DH. Mechanisms of intracellular killing of Rickettsia conorii in infected human endothelial cells, hepatocytes, and macrophages. Infect Immun 2000; 68:6729–6736. 28. Walker DH, Staiti A, Mansueto S, et al. Frequent occurrence of hepatic lesions in boutonneuse fever.
Conorii genome reveals five spoT paralogs, and environmental stress conditions are accompanied by a variable spoT1 transcription in R. conorii (55). This phenomenon could play a role in adaptation of rickettsiae to ticks and during the process of reactivation.
Variabilis (32), R. slovaca in D. marginatus (24), and R. massiliae in Rh. sanguineus group ticks (31), maintenance of rickettsiae via TOT may reach 100% and have no effect on the reproductive fitness and viability of the tick host. In contrast, TOT of R. rickettsii in D. andersoni diminishes survival and reproductive capacity of progeny (34). Recent experiments have shown that R. rickettsii is lethal for the majority of experimentally and transovarially infected D. andersoni. In one study, most nymphs infected as larvae by feeding on rickettsemic guinea pigs died during the molt into adults, and most of adult female ticks infected as nymphs died prior to feeding.
Rickettsial Diseases by Didier Raoult, Philippe Parola
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