By Robert Chilcott, Shirley Price
ISBN-10: 0470511729
ISBN-13: 9780470511725
Written by way of gurus within the box, this booklet offers a “bottom up” method of learning pores and skin toxicology. ideas and perform of pores and skin Toxicology truly outlines uncomplicated ideas, cites ancient and sleek references and incorporates a dictionary for simple reference. The inclusion of world laws and regulatory facets at the subject makes this a complete assessment for each practitioner, scientific researcher in and academia, and MSc and PhD scholar of toxicology. diverse sections conceal dermis constitution and serve as, ideas and size of epidermis absorption, scientific elements of dermal toxicity and in vitro alternatives. A part on regulatory and legislative features contains case experiences from the united kingdom that satisfy ecu Union and US FDA requirements.A glossary presents definitions of technical phrases, and the chapters include an creation, studying boxes and precis part for ease of use. Includes a bankruptcy on drug supply throughout the skin.Addresses danger overview: a key quarter for the translation of pores and skin absorption info that's hardly coated.
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Extra info for Principles and Practice of Skin Toxicology
Example text
There are, however, some notable absences of CYP activity in skin. For example, CYP2A6 activity was not detected in human or rodent skin tissue (Beckley-Kartey et al. 1997). Comparisons of enzyme-specific activity towards probe substrates between skin and liver vary considerably. 5–7% and PROD activity from 20–27% of hepatic activity respectively (Mukhtar and Khan 1989). 6: BIOTRANSFORMATIONS IN SKIN 29 with hepatocytes on a per cell basis (Reiners et al. 5-fold higher than in HaCaT cells (Ledirac et al.
This forms a thin film on the skin surface and is comprised of sebum, corneocyte debris and residual material from sweat. This mixture of substances generally imparts a low pH on the skin surface owing to the presence of free fatty acids and, being predominantly lipophilic, may conceivably influence the partitioning of substances into the skin or act as an adsorbent matrix to trap microscopic particles such as dirt, dust or powders. The predominant component of the acid mantle is sebum, considered by some to be vestigial (Kligman 1963).
2001; Egberts et al. 2004). Transglutaminase activity appears to be under the control of Cathepsin D (Egberts et al. 2004), an aspartic peptidase (Fusek and Vetvicka 2005). Transglutaminase can also catalyse the ester linkage of acyl chains of ceramides in the nearest lipid layer to the corneocyte envelope (see below). 3 Lipid synthesis and organisation during epidermal differentiation The lipid components of the stratum corneum are synthesised in the stratum granulosum, where they are packaged into lamellar bodies prior to apical secretion into the intercorneocyte spaces to form the lipid mortar.
Principles and Practice of Skin Toxicology by Robert Chilcott, Shirley Price
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