Diuretic Agents: Clinical Physiology and Pharmacology by Donald W. Seldin, Gerhard H. Giebisch PDF

By Donald W. Seldin, Gerhard H. Giebisch

ISBN-10: 0126356904

ISBN-13: 9780126356908

The single accomplished paintings to hide all facets of diuretic brokers, the e-book discusses the pharmacology and toxicology of diuretic brokers in addition to the physiological results. specialists within the box current the foundations and experimental methods for the learn of interactions among pharmacologic compounds when it comes to particular goal organs. Diuretic Agents includes details at the mechanisms of motion and alertness of diuretics, and information FDA rules and pharmaceutical guidance.

Key Features
* Written by way of specialists within the field
* Covers all elements of diuretic agents
* comprises info at the mechanisms of motion and alertness of diuretics

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Sample text

Because the proximal tubule is highly permeable to water (see below), the total concentration of solutes in the luminal fluid remains relatively constant along the length of the tubule. Thus, the active reabsorption of organic solutes Cl- HC03 Organic Length of the Proximal Tubule solute FIGURE 5. Profileof solute concentrations along the length of the proximal tubule. The ratio of tubular fluid to plasma solute concentration (TF/P) is plotted as a function of length along the proximal tubule. Active reabsorption of organic solutes with secondary water reabsorption leads to decreases in luminal organic solute concentrations and small increases in the luminal concentrations of Na ยง and C1-.

17, 1-10. 6. Binger, M. , and Keith, N. M. (1933). The effects of diuretics in different types of edema. J. Am. Med. Assoc. 101, 2009- 2016. 7. Brain, P. (1979). In defence of ancient bloodletting. South Am. J. 56, 149-154. 8. Castiglioni, A. (1947). "A History of Medicine," 2nd ed. Knopf, New York. 9. Comroe, J. , Jr. (1983). "Exploring the Heart. " Norton, New York. 10. Cragoe, E. , Jr. ) (1983). " Wiley, New York. 11. Crawford, J. , and McDaniel, W. S. (1935). Some observations on mercurial diuretics.

The diuretic properties of mercury were recognized by Paracelsus, in his quest for "specific" remedies derived from chemicals [25]. His report in 1553 of the diuretic action of mercury and its curative effect in dropsy is quite revealing: Mercury is the specific remedy in dropsy. This is due to a morbid extraction of salt from the flesh, a chemical process of solution and coagulation. As such this process does not depend at all upon quality and complexion, but is a "celestial virtue" endowed with its own "monarchy" to which quality and complexion are subservient.

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Diuretic Agents: Clinical Physiology and Pharmacology by Donald W. Seldin, Gerhard H. Giebisch


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