By Werner Kempf
A sound historical past in dermatopathology is vital for the prognosis of either inflammatory dermatoses and cutaneous tumors. This booklet presents an advent to the foundations of dermatopathology, aimed essentially at dermatologists and pathologists in education, yet precious for a large audience
Everyone drawn to dermatopathology will cash in on mixed wisdom of four skilled dermatopathologists, uniform constitution strategy targeting universal diagnoses, logical presentation of medical and histological good points, huge essentially categorised illustrations, clues for differential diagnostic considerations.
All photographs are in colour, published on top quality paper, essentially classified and designed to assist each reader become proficient at choosing either styles and particular diagnostic beneficial properties rapidly.
A dermatopathology designed for use, not only learn – written by means of practitioners for day-by-day practice.
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Additional info for Dermatopathology
Smaller lesions often lack dell. More common in children, especially those with atopic dermatitis. In adults usually anogenital Histopathology Circumscribed multilobular epithelial proliferation with central keratinization Intracytoplasmic inclusions, at the periphery eosinophilic and towards the center of the tumor more basophilic Associated mixed or lymphocytic infiltrate Occasionally lymphocytes are activated and enlarged Variant Molluscum contagiosum folliculitis: Involvement of follicular epithelia with inclusion bodies and associated mixed infiltrate Differential diagnoses The histological changes are pathognomonic.
At periphery apoptotic keratinocytes. Minimal lymphocytic infiltrate ] Phytophototoxic reaction Apoptotic keratinocytes and epidermal necrosis. Marked edema with subepidermal blisters. Minimal infiltrate ] Acute graft-versus-host reaction Apoptotic keratinocytes, satellite cell necrosis, vacuolar change at DEJ, sparse lichenoid infiltrate, occasional eosinophils, no edema ] Fixed drug eruption Incontinence of pigment. Apoptotic keratinocytes, satellite cell necrosis, vacuolar changes at DEJ, superficial lymphocytic perivascular infiltrate with eosinophils and neutrophils.
Verruca plana: polygonal flat papules without marked hyperkeratosis . Condyloma acuminatum: hyperpigmented or skin-colored papule without hyperkeratosis in anogenital area Histopathology Verruca vulgaris Focal acanthosis and papillomatosis with confluence of elongated rete ridges Hyperparakeratosis with focal parakeratosis and hemorrhage over the papillary tips Koilocytes with clear cytoplasm, condensed nuclei in granular layer Ectatic capillaries in papillae Variable lymphocytic infiltrate Condyloma acuminatum Broad-based acanthosis, papillomatosis, no hyperkeratosis Focal parakeratosis Few koilocytes, sparse infiltrate Differential diagnoses ] Seborrheic keratosis Broad-based localized acanthosis, intraepithelial horn cysts.
Dermatopathology by Werner Kempf