By Mario E. Lacouture
This can be the 1st booklet to target widespread and often disabling uncomfortable side effects concerning the outside, hair, and nails in melanoma sufferers. It offers precise descriptions of mechanism-of-action in all present oncology medicines and the medical presentation and mechanisms underlying their dermatologic unintended effects, along rigorously provided remedy thoughts, permitting physicians to seriously improve their care of sufferers with melanoma. while latest oncology and dermatology textbooks merely in brief care for this subject, this source bargains dermatologists and different practitioners a concentrated point of view on cancer-related epidermis stipulations.
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Additional resources for Dermatologic Principles and Practice in Oncology: Conditions of the Skin, Hair, and Nails in Cancer Patients
Approximately 1% of telogen hairs (100–150 hairs) are normally shed from the scalp daily. 44 mm/day or approximately 1 cm/month. Chemotherapeutics represent the most common causes of anagen effluvium. As most hair follicles are in the anagen stage at any given time, anagen effluvium affects the majority of scalp hair. Hair is further classified according to size. Terminal hairs are at least 60 μm in diameter and are found on the scalp, eyebrows, and eyelashes at birth. The length of the terminal hair is determined by the duration of the anagen growth phase.
It is organized into two portions: 1. The upper papillary dermis, which hugs the epidermis and is made up of loosely arranged collagen fibers; and 2. The reticular dermis, which makes up almost the entire thickness of the dermis. The connective tissue matrix of the reticular dermis is composed of interwoven bundles of densely packed helical collagen fibrils surrounded by elastic fibers. Type I collagen makes up 80–90% of dermal collagen. The matrix also contains glycoproteins, proteoglycans, and glycosaminoglycans that form the water binding ground substance of the dermis.
Cancer, 109, 322–331. H. L. (1955) Aminopterin for psoriasis. A. M. A. Archives of Dermatology, 72, 133–143. G. Jr, Maekawa, T. M. (1958) The influence of 1,4-dimethyl sulfonoxy-1,4dimethylbutane (CB 2348, Dimethyl Myleran) in neoplastic disease. Annals of the New York Academy of Sciences, 68, 1211–1222. , Lu, Z. L. (2006) Protection against chemotherapyinduced alopecia. Pharmaceutical Research, 23, 2505–2514. C. M. (2001) Psychological sequelae and alopecia among women with cancer. Cancer Practice, 9, 283–289.
Dermatologic Principles and Practice in Oncology: Conditions of the Skin, Hair, and Nails in Cancer Patients by Mario E. Lacouture