Read e-book online Dermal Absorption Models in Toxicology and Pharmacology PDF

By Jim E. Riviere, Nancy A. Monteiro-Riviere

ISBN-10: 0415700361

ISBN-13: 9780415700368

Many experimental tools and mathematical modeling techniques rooted in disciplines open air of toxicology might be successfully utilized to estimating dermal absorption. Dermal Absorption types in Toxicology and Pharmacology explores present methods and methods that may be used to quantify dermal absorption with endpoints valuable in either toxicology and pharmacology.
The booklet starts with a overview of easy rules and the in vitro and in vivo experimental methods on hand for assessing dermal absorption of gear and chemical substances. this is often by means of insurance of mathematical or in silico versions for quantitating percutaneous absorption and the purposes of those ideas to the chance overview method. the rest of the booklet explores situations the place the original homes of the chemical compounds being studied or the matrix within which they're uncovered has to be thought of after which wraps up with a comparative research of chemical permeability in human and animal skin.
Many of the books masking this topic are only too entire and serve essentially as reference works. This publication takes a unique procedure. Jim Riviere's editorial counsel guarantees that the data is readable, obtainable, authoritative, and concise, making it the correct source for familiarizing new researchers and scholars to the sphere and updating tested scientists.

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1998). , 2002). RECEPTOR FLUID In vitro skin absorption studies often differ in the receptor fluid used. , 1989). , 1989). Modifications of the receptor fluid are sometimes made to facilitate the partitioning of lipophilic chemicals from skin into the receptor fluid to simulate the 24 DERMAL ABSORPTION MODELS IN TOXICOLOGY AND PHARMACOLOGY in vivo absorption process. The addition of 3 to 5% bovine serum albumin is a mild, more physiological adjustment that can be useful but often does not provide sufficient lipid solubility to the receptor fluid (Bronaugh and Stewart, 1986).

1996, The in vitro percutaneous absorption of the fragrance ingredient musk xylol, Food Chem. , 34:483–488. L. , 9:221–230. , 1992, Cutaneous metabolism of xenobiotics and steroid hormones, in Pharmacology of the Skin (Ed. H. Mukhtar), CRC Press, Boca Raton, FL, pp. 89–109. , 1991, Reductive metabolism of nitro-pphenylenediamine by rat liver, Chem. Pharm. , 39:177–180. , 1992, Percutaneous absorption and metabolism of pyrene, benzo[a]pyrene, and di(2-ethylhexyl) phthalate: comparison of in vitro and in vivo results in the hairless guinea pig, Toxicol.

1984, Absorption of some glycol ethers through human skin in vitro, Environ. , 57:193–197. , 1975, On the relevance of in vitro data, J. Invest. , 64:190–195. , 1996, The in vitro percutaneous absorption of the fragrance ingredient musk xylol, Food Chem. , 34:483–488. L. , 9:221–230. , 1992, Cutaneous metabolism of xenobiotics and steroid hormones, in Pharmacology of the Skin (Ed. H. Mukhtar), CRC Press, Boca Raton, FL, pp. 89–109. , 1991, Reductive metabolism of nitro-pphenylenediamine by rat liver, Chem.

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Dermal Absorption Models in Toxicology and Pharmacology by Jim E. Riviere, Nancy A. Monteiro-Riviere


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