Download PDF by Lawrence S Chan: Blistering Skin Diseases

By Lawrence S Chan

ISBN-10: 1840760664

ISBN-13: 9781840760668

ISBN-10: 1840765119

ISBN-13: 9781840765113

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Sample text

LICHEN PLANUS PEMPHIGOIDES í Lexicon-format morphological terminology • • • • • • • • • • • Primary lesions: vesicle; bulla; papule; plaque Secondary features: crusting; scales Individual lesions: round; oval; annular; polygonal Multiple lesion arrangements: scattered skin Distribution: scattered skin Locations: scattered skin Signs: Koebner; Wickham striae Textures and patterns: lichenoid; Wickham striae Consistency: firm; tense Color of lesions: skin; erythematous; violaceous Color of body: normal 54 Lichen planus pemphigoides manifests with vesicles and bullae, on both normalappearing skin and on violaceous lichen planus papules and plaques, commonly involving the extremities.

Typical cases consist of clinical phenotypes and diagnostic findings of both pemphigus foliaceus and systemic lupus erythematosus [76; 79]. The clinical phenotype of PE consists of erythematous papules and plaques, as well as vesicles and crusting erosion, located in a seborrheic- (26) or butterfly-like pattern on the malar area. Other photo-distributed areas, such as upper back and chest, are commonly involved (27). Thymoma and myasthenia gravis are occasionally reported disease associations of PE [84].

The humanized mouse anti-CD20 antibody, rituximab, has shown great potential in treating patients with pemphigus vulgaris and may also be beneficial for patients affected by pemphigus vegetans. In addition, extracorporeal photophoresis has been shown to be effective [52a]. 21 Flaccid blisters mark the initial clinical presentation of pemphigus foliaceus. 22 í PEMPHIGUS FOLIACEUS í Lexicon-format morphological terminology • Primary lesions: vesicle and bulla • Secondary (and predominant) features: crusting; erosion; exudates; scale; exfoliation; postinflammatory hyperpigmentation • Individual lesions: round or oval • Multiple lesion arrangements: scattered • Distribution: seborrheic • Locations: generalized skin, concentrating on scalp, face, upper back, and chest • Signs: Nikolsky • Textures and patterns: none • Consistency: flaccid • Color of lesions: skin; erythematous • Color of body: normal Epidemiology Like pemphigus vulgaris, pemphigus foliaceus (PF) affects men and women equally.

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Blistering Skin Diseases by Lawrence S Chan


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