By Matt Kalaycio
The Cleveland hospital origin, OH. textual content covers information regarding new biologic treatments and gives the health care provider with useful information for treating sufferers with leukemia. Discusses such remedies as arsenic trioxide, P-glycoprotein inhibitors, and interleukins. additionally covers genetic code changes. DNLM: Leukemia, remedy.
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Extra info for Biologic Therapy of Leukemia
Prospective comparative trial of autologous versus allogeneic bone marrow transplantation in patients with non-Hodgkin’s lymphoma. Blood 1994;84:1050–1055. 16. Björkstrand B, Ljungman P, Svensson H, et al. Allogeneic bone marrow transplantation versus autologous stem cell transplantation in multiple myeloma: a retrospective case-matched study from the european group for blood and marrow transplantation. Blood 1996;88:4711–4718. 17. Tricot G, Vesole D, Jagannath S, Holton J, Munshi N, Barlogie B.
Of 22 patients in first remission of APL but who were still PCR positive for PML/RARα, 11 (50%) achieved molecular complete remission after treatment with HuM195 3mg/m2 twice weekly for six doses (11). This study demonstrates proof of principle that HuM195 is capable of eliminating minimal residual disease in patients with APL. Chapter 3 / Unconjugated Monoclonal Antibodies 31 In a larger study of patients with advanced AML, HuM195 was administered to 49 patients with active leukemia. Patients were randomized to either a 12-mg/m2 infusion or a 36-mg/m2 infusion administered weekly for 4 wk.
24 Bolwell 3. Odom L, Githens J, Morse H, et al. Remission of relapsed leukaemia during a graft-versushost reaction. Lancet 1978;2:537–540. 4. Weiden P, Flournoy N, Thomas E, et al. Antileukemic effect of graft-versus-host disease in human recipients of allogeneic-marrow grafts. N Engl J Med 1979;300:1068–1073. 5. Sullivan K, Storb R, Buckner C, et al. Graft-versus-host disease as adoptive immunotherapy in patients with advanced hematologic neoplasms. N Engl J Med 1989;320:828–834. 6. Sullivan K, Weiden P, Storb R, et al.
Biologic Therapy of Leukemia by Matt Kalaycio