By Michael E. Swartz
ISBN-10: 0824719395
ISBN-13: 9780824719395
Info tools at present on hand and discusses rising options which could have an immense influence. Highlights post-synthesis processing options.
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Collect-beforedetect methods are those where product collection is based on a predetermined scheme and is not guided by real-time product detection. Such methods are suitable only when the chromatographic properties of the products can be predicted with confidence. Applications that fall into this category include ion exchange chromatography using solid phase extraction cartridges and apparatus (69). However, similar methods using pure adsorption chromatography provide much less predictable elution and are less amenable to highthroughput purification of a diverse combinatorial library.
SUMMARY The drug discovery process is a complex and dynamic continuum ranging from early phase lead discovery, through lead optimization, to candidate selection. The field of combinatorial chemistry provides a continuum of methods to support drug discovery. These methods range from split-and-pool synthesis of large libraries, through encoded synthesis of medium size libraries, and to parallel synthesis of smaller libraries of highly purified compounds. A successful drug discovery program will match the combinatorial chemistry methods used with the demands of the overall program at any point in time.
Surface Enhanced Affinity Capture and Probe Affinity Mass Spectrometry One of the advantages of matrix-assisted laser desorption ionization (MALDI) is its sensitivity. As described above, MALDI can be extremely useful for the identification of solid phase combinatorial library components and even sequencing of peptide libraries using a single bead. Therefore, it is also a useful technique for screening combinatorial libraries where sample quantities do not permit the application of immunoaffinity HPLC-MS or ultrafiltration techniques with high flow rates, limited sensitivity, and significant consumption of receptor.
Analytical Techniques in Combinatorial Chemistry by Michael E. Swartz
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