By Esen Özkaya, Kurtuluş Didem Yazganoğlu
Adverse cutaneous drug reactions (ACDR) are one of the such a lot widespread occasions in sufferers receiving drug treatment. Cardiovascular (CV) medicinal drugs are a tremendous team of substances with capability danger of constructing ACDR specially in aged as advertising and marketing of extra new medicinal drugs and their prescription proceed to extend. although, like with such a lot different medications the precise occurrence of cutaneous uncomfortable side effects from CV medicines is tough to estimate because of sporadic reporting. furthermore, a competent designation of a definite drug because the reason for a definite form of response can infrequently be made. except the well known angioedema/urticaria from ACE inhibitors, lichen planus / lichenoid response from beta adrenergic blockers and photosensitivity from thiazid diuretics, ACDR from CV medications will be noticeable in a large spectrum extending to infrequent yet life-threatening stipulations similar to erythroderma, Stevens-Johnson syndrome, poisonous epidermal necrolysis or drug allergy syndrome. during this entire assessment, the pronounced kinds of ACDR to CV medicinal drugs can be mentioned in response to drug category and the kind of dermatologic response with distinctive emphasize on cross-reactions and the function of patch checking out in diagnosis.
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Additional resources for Adverse Cutaneous Drug Reactions to Cardiovascular Drugs
The generalized form of pustular eruption characterized by acute extensive formation of sterile small superficial pustules on an erythematous base, often accompanied by a high fever and peripheral blood leukocytosis, is called AGEP (Figs. 41). It usually starts within 3–5 days of therapy with the causative drug . There is typically no mucosal involvement. Diagnostic criteria and a scoring system based on the morphological and histopathological features and the course of disease have been defined for the diagnosis of AGEP [33, 34].
Antiepileptics such as carbamazepine and lamotrigine, sulfonamides, allopurinol, terbinafine, vancomycin , and more recently new retroviral drugs  are among the main inducers of DHS/DRESS. The reaction has a long latency period up to 8 weeks after starting the responsible drug . The long latency period and fever as the initial symptom may complicate the early diagnosis of the condition. Phenytoin when used as antiepileptic drug is frequently associated with DHS/ DRESS. Withdrawal of the offending drug and treatment with systemic corticosteroids are usually effective.
There is a tendency towards secondary infection. Sulfonamides, allopurinol, barbiturates, hydantoin derivatives, phenylbutazone, carbamazepine, NSAIDs, gold salts, and lithium are among the common inducers Characteristic Features of Adverse Cutaneous Drug Reactions Fig. 55 Erythroderma/ exfoliative dermatitis showing diffuse erythema and desquamation of the skin Fig. 56 Erythroderma/ exfoliative dermatitis showing widespread confluent erythema and desquamation of the skin 35 36 1 General Aspects of Adverse Cutaneous Drug Reactions Fig.
Adverse Cutaneous Drug Reactions to Cardiovascular Drugs by Esen Özkaya, Kurtuluş Didem Yazganoğlu