By Alan R. Shalita, James Q. Del Rosso, Guy Webster
The American zits and Rosacea Society is devoted to advancing the technology concerning pimples and rosacea and to improving conversation among these attracted to those illnesses. this article isn't really intended to be a accomplished treatise on all points of zits, yet fairly to deal with significant attractions by way of stated notion leaders within the box within the desire that it'll bring about extra learn, dialogue, and refinement of our techniques of either the pathogenesis and the remedy of acne.
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Additional resources for Acne Vulgaris
Impli cations for antimicrobial treatment. Am J Clin Dermatol 2000; 1:201 209. 47. Guy R, Kealey T. Modeling the infundibulum in acne. Dermatology 1998; 196:32 37. 48. Webster GF. Inflammation in acne vulgaris. J Am Acad Dermatol 1995; 33: 247 253. 49. Eady EA, Ingham E, Walters CE, et al. Modulation of comedonal levels of interleukin 1 in acne patients treated with tetracyclines. J Invest Dermatol 1993; 101:86 91. 50. Kealey T, Guy R. Modeling the infundibulum in acne. J Invest Dermatol 1997; 108:376.
Acnes induces IL-12 and IL-8 production by human monocytes via activation of TLR2. They also demonstrated that TLR2 expression was found in macrophages in biopsied acne lesions, particularly in the perifollicular regions, and the quantity of TLR2positive cells detected increased with the increasing age of the lesion. Following these findings, Jugeau et al. demonstrated that TLR2 and TLR4 expression are upregulated in acne lesions of patients with facial acne and that TLR2 and TLR4 expression increased within hours of incubating human keratinocytes with 18 INNATE IMMUNITY IN THE PATHOGENESIS OF ACNE VULGARIS bacterial fractions (49).
Nagy I, Pivarcsi A, Kis K, et al. Propionibacterium acnes and lipopolysaccharide induce the expression of antimicrobial peptides and proinflammatory cytokines/ chemokines in human sebocytes. Microbes Infect 2006; 8:2195 2205. 22. Chronnell CM, Ghali LR, Ali RS, et al. Human beta defensin 1 and 2 expression in human pilosebaceous units: upregulation in acne vulgaris lesions. J Invest Dermatol 2001; 117:1120 1125. 23. Zouboulis CC, Baron JM, Bohm M, et al. Frontiers in sebaceous gland biology and pathology.
Acne Vulgaris by Alan R. Shalita, James Q. Del Rosso, Guy Webster